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1

Conditional Disruption Of Beta 1 Integrin In Schwann Cells Impedes Interactions With Axons

ML Feltri, DG Porta, SC Previtali, A Nodari, B Migliavacca, A Cassetti, A Littlewood-Evans, LF Reichardt, A Messing, A Quattrini, U Mueller, L. Wrabetz

Journal:

Journal of the Peripheral Nervous System

Year:

2002

Language:

english

File:

PDF, 74 KB

english, 2002

2

Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Brutonâs Tyrosine Kinase

Angst, Daniela, Gessier, FranÃ§ois, Janser, Philipp, Vulpetti, Anna, WÃ¤lchli, Rudolf, Beerli, Christian, Littlewood-Evans, Amanda, Dawson, Janet, Nuesslein-Hildesheim, Barbara, Wieczorek, Grazyna, Gu

Journal:

Journal of Medicinal Chemistry

Year:

2020

Language:

english

File:

PDF, 1.01 MB

english, 2020

3

Genes, deafness, and balance disorders

Jan Siemens, Amanda Littlewood-Evans, Mathias Senften, Ulrich Müller

Journal:

Gene Function & Disease

Year:

2001

Language:

english

File:

PDF, 1.33 MB

english, 2001

4

The critical role of kinase activity of interleukin-1 receptor–associated kinase 4 in animal models of joint inflammation

Magdalena Koziczak-Holbro, Amanda Littlewood-Evans, Bernadette Pöllinger, Jiri Kovarik, Janet Dawson, Gerhard Zenke, Christoph Burkhart, Matthias Müller, Hermann Gram

Journal:

Arthritis & Rheumatism

Year:

2009

Language:

english

File:

PDF, 985 KB

english, 2009

5

In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part II

Laszlo Revesz, Achim Schlapbach, Reiner Aichholz, Janet Dawson, Roland Feifel, Stuart Hawtin, Amanda Littlewood-Evans, Guido Koch, Markus Kroemer, Henrik Möbitz, Clemens Scheufler, Juraj Velcicky, Chr

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 888 KB

english, 2010

6

αβ1 Integrins Are Required For Normal Peripheral Nerve Development

ML Feltri, A Quattrini, S Previtali, A Nodari, B Migliavacca, D Graus-Porta, A Littlewood-Evans, A Messing, U Mueller, L. Wrabetz

Journal:

Journal of the Peripheral Nervous System

Year:

2001

Language:

english

File:

PDF, 204 KB

english, 2001

7

Everolimus and PTK/ZK show synergistic growth inhibition in the orthotopic BL16/BL6 murine melanoma model

Terence O’Reilly, Heidi A. Lane, Jeanette M. Wood, Christian Schnell, Amanda Littlewood-Evans, Josef Brueggen, Paul M. J. McSheehy

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2011

Language:

english

File:

PDF, 401 KB

english, 2011

8

Regulation of epidermal homeostasis through P2Y2 receptors

C Jane Dixon, Wayne B Bowler, Amanda Littlewood-Evans, Jane P Dillon, Graeme Bilbe, Graham R Sharpe, James A Gallagher

Journal:

British Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 727 KB

english, 1999

9

Mechanisms that regulate mechanosensory hair cell differentiation

Ulrich Müller, Amanda Littlewood-Evans

Journal:

Trends in Cell Biology

Year:

2001

Language:

english

File:

PDF, 150 KB

english, 2001

10

β1-Class Integrins Regulate the Development of Laminae and Folia in the Cerebral and Cerebellar Cortex

Diana Graus-Porta, Sandra Blaess, Mathias Senften, Amanda Littlewood-Evans, Caroline Damsky, Zhen Huang, Paul Orban, Rüdiger Klein, Johannes C. Schittny, Ulrich Müller

Journal:

Year:

2001

Language:

english

File:

PDF, 2.72 MB

english, 2001

11

P2Y2 receptors are expressed by human osteoclasts of giant cell tumor but do not mediate ATP-induced bone resorption

W.B. Bowler, A. Littlewood-Evans, G. Bilbe, J.A. Gallagher, C.J. Dixon

Journal:

Year:

1998

Language:

english

File:

PDF, 1.09 MB

english, 1998

12

Inhibition of Chronic and Acute Skin Inflammation by Treatment with a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor

Cornelia Halin, Hermann Fahrngruber, Josef G. Meingassner, Guido Bold, Amanda Littlewood-Evans, Anton Stuetz, Michael Detmar

Journal:

The American Journal of Pathology

Year:

2008

Language:

english

File:

PDF, 1.57 MB

english, 2008

13

Angiogenesis is present in experimental autoimmune encephalomyelitis and pro-angiogenic factors are increased in multiple sclerosis lesions

Timothy J Seabrook, Amanda Littlewood-Evans, Volker Brinkmann, Bernadette Pöllinger, Christian Schnell, Peter C Hiestand

Journal:

Journal of Neuroinflammation

Year:

2010

Language:

english

File:

PDF, 1.92 MB

english, 2010

14

49 POSTER Experimental tumor models with high LDH activity are efficiently targeted by treatment with PTK787/ZK222584, an oral multi-VEGF tyrosine kinase inhibitor

H. Hess-Stumpp, K.H. Thierauch, B. Riefke, C. Schnell, A. Littlewood-Evans

Journal:

European Journal of Cancer Supplements

Year:

2006

Language:

english

File:

PDF, 88 KB

english, 2006

15

Localization of cathepsin K in human osteoclasts by in situ hybridization and immunohistochemistry

A. Littlewood-Evans, T. Kokubo, O. Ishibashi, T. Inaoka, B. Wlodarski, J.A. Gallagher, G. Bilbe

Journal:

Year:

1997

Language:

english

File:

PDF, 1.02 MB

english, 1997

16

Reviews and Notices of Books.

Littlewood-Evans, A., Hattenberyer, M., Kunz, S., Zak, O., O'Reilly, T.

Journal:

Year:

1919

Language:

english

File:

PDF, 435 KB

english, 1919

17

Elevated bone tnf levels during experimental osteomyelitis are not reduced by antibacterial treatment

Littlewood-Evans, A., Hattenberyer, M., Kunz, S., Zak, O., O'Reilly, T.

Journal:

Year:

1995

Language:

english

File:

PDF, 143 KB

english, 1995

18

Contextual Compound Screening for Improved Therapeutic Discovery

Evensen, Lasse, Odlo, Kristin, Micklem, David R., Littlewood-Evans, Amanda, Wood, Jeanette, Kuzniewski, Christian, Altmann, Karl-Heinz, Hansen, Trond Vidar, Lorens, James B.

Journal:

Year:

2013

Language:

english

File:

PDF, 2.59 MB

english, 2013

19

Discovery and Profiling of a Selective and Efficacious Syk Inhibitor

Thoma, Gebhard, Smith, Alexander B., van Eis, Maurice J., Vangrevelinghe, Eric, Blanz, Joachim, Aichholz, Reiner, Littlewood-Evans, Amanda, Lee, Christian C., Liu, Hong, Zerwes, Hans-Günter

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.43 MB

english, 2015

20

Th17 Cells, Not IL-17+ T Cells, Drive Arthritic Bone Destruction in Mice and Humans

Pollinger, B., Junt, T., Metzler, B., Walker, U. A., Tyndall, A., Allard, C., Bay, S., Keller, R., Raulf, F., Di Padova, F., O'Reilly, T., Horwood, N. J., Patel, D. D., Littlewood-Evans, A.

Journal:

The Journal of Immunology

Year:

2011

Language:

english

File:

PDF, 2.02 MB

english, 2011

21

The Tyrosine Kinase BMX Is an Essential Mediator of Inflammatory Arthritis in a Kinase-Independent Manner

Gottar-Guillier, M., Dodeller, F., Huesken, D., Iourgenko, V., Mickanin, C., Labow, M., Gaveriaux, S., Kinzel, B., Mueller, M., Alitalo, K., Littlewood-Evans, A., Cenni, B.

Journal:

The Journal of Immunology

Year:

2011

Language:

english

File:

PDF, 1.67 MB

english, 2011

22

The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions

Siemens, J., Kazmierczak, P., Reynolds, A., Sticker, M., Littlewood-Evans, A., Muller, U.

Journal:

Proceedings of the National Academy of Sciences

Year:

2002

Language:

english

File:

PDF, 360 KB

english, 2002

23

Effect of combination therapy of rifampicin and azithromycin on TNF levels during a rat model of chronic osteomyelitis

Littlewood-Evans, A.

Journal:

Journal of Antimicrobial Chemotherapy

Year:

1997

Language:

english

File:

PDF, 753 KB

english, 1997

24

Effects of the Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 on the Tumor Vasculature: Implications for Clinical Imaging

Schnell, C. R., Stauffer, F., Allegrini, P. R., O'Reilly, T., McSheehy, P. M.J., Dartois, C., Stumm, M., Cozens, R., Littlewood-Evans, A., Garcia-Echeverria, C., Maira, S.-M.

Journal:

Cancer Research

Year:

2008

Language:

english

File:

PDF, 843 KB

english, 2008

25

Inhibition of Multiple Vascular Endothelial Growth Factor Receptors (VEGFR) Blocks Lymph Node Metastases but Inhibition of VEGFR-2 Is Sufficient to Sensitize Tumor Cells to Platinum-Based Chemotherapeutics

Sini, P., Samarzija, I., Baffert, F., Littlewood-Evans, A., Schnell, C., Theuer, A., Christian, S., Boos, A., Hess-Stumpp, H., Foekens, J. A., Setyono-Han, B., Wood, J., Hynes, N. E.

Journal:

Cancer Research

Year:

2008

Language:

english

File:

PDF, 1.28 MB

english, 2008

26

Biological Evidence for Dual Antiangiogenic-Antiaromatase Activity of the VEGFR Inhibitor PTK787/ZK222584 In vivo

Banerjee, S., A'Hern, R., Detre, S., Littlewood-Evans, A. J., Evans, D. B., Dowsett, M., Martin, L.-A.

Journal:

Clinical Cancer Research

Year:

2010

Language:

english

File:

PDF, 669 KB

english, 2010

27

Differential effects of the vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 on tumor angiogenesis and tumor lymphangiogenesis

Schomber, T., Zumsteg, A., Strittmatter, K., Crnic, I., Antoniadis, H., Littlewood-Evans, A., Wood, J., Christofori, G.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 536 KB

english, 2009

28

mTOR Inhibitor RAD001 (Everolimus) Has Antiangiogenic/Vascular Properties Distinct from a VEGFR Tyrosine Kinase Inhibitor

Lane, H. A., Wood, J. M., McSheehy, P. M.J., Allegrini, P. R., Boulay, A., Brueggen, J., Littlewood-Evans, A., Maira, S.-M., Martiny-Baron, G., Schnell, C. R., Sini, P., O'Reilly, T.

Journal:

Clinical Cancer Research

Year:

2009

Language:

english

File:

PDF, 560 KB

english, 2009

29

Conditional Disruption of β1 Integrin in Schwann Cells Impedes Interactions with Axons

M. Laura Feltri, Diana Graus Porta, Stefano C. Previtali, Alessandro Nodari, Barbara Migliavacca, Arianna Cassetti, Amanda Littlewood-Evans, Louis F. Reichardt, Albee Messing, Angelo Quattrini, Ulrich

Journal:

The Journal of Cell Biology

Year:

2002

Language:

english

File:

PDF, 2.64 MB

english, 2002

30

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

Littlewood-Evans, Amanda, Sarret, Sophie, Apfel, Verena, Loesle, Perrine, Dawson, Janet, Zhang, Juan, Muller, Alban, Tigani, Bruno, Kneuer, Rainer, Patel, Saijel, Valeaux, Stephanie, Gommermann, Nina,

Journal:

Journal of Experimental Medicine

Year:

2016

Language:

english

File:

PDF, 1.53 MB

english, 2016

31

Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis

Velcicky, Juraj, Miltz, Wolfgang, Oberhauser, Berndt, Orain, David, Vaupel, Andrea, Weigand, Klaus, Dawson King, Janet, Littlewood-Evans, Amanda, Nash, Mark, Feifel, Roland, Loetscher, Pius

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.88 MB

english, 2017

32

Mural Cell Associated VEGF Is Required for Organotypic Vessel Formation

Evensen, Lasse, Micklem, David R., Blois, Anna, Berge, Sissel Vik, Aarsæther, Niels, Littlewood-Evans, Amanda, Wood, Jeanette, Lorens, James B., Cao, Yihai

Journal:

Year:

2009

Language:

english

File:

PDF, 7.10 MB

english, 2009

33

Small-molecule factor B inhibitor for the treatment of complement-mediated diseases

Schubart, Anna, Anderson, Karen, Mainolfi, Nello, Sellner, Holger, Ehara, Takeru, Adams, Christopher M., Mac Sweeney, Aengus, Liao, Sha-Mei, Crowley, Maura, Littlewood-Evans, Amanda, Sarret, Sophie, W

Journal:

Proceedings of the National Academy of Sciences

Year:

2019

Language:

english

File:

PDF, 1.20 MB

english, 2019

34

Structural basis of species-selective antagonist binding to the succinate receptor

Haffke, Matthias, Fehlmann, Dominique, Rummel, Gabriele, Boivineau, Jacques, Duckely, Myriam, Gommermann, Nina, Cotesta, Simona, Sirockin, Finton, Freuler, Felix, Littlewood-Evans, Amanda, Kaupmann, K

Journal:

Year:

2019

File:

PDF, 11.90 MB

2019

35

The NLRP3 inflammasome pathway is activated in sarcoidosis and involved in granuloma formation

Huppertz, Christine, Jäger, Benedikt, Wieczorek, Grazyna, Engelhard, Peggy, Oliver, Stephen J., Bauernfeind, Franz-Georg, Littlewood-Evans, Amanda, Welte, Tobias, Hornung, Veit, Prasse, Antje

Journal:

European Respiratory Journal

Year:

2020

Language:

english

File:

PDF, 3.69 MB

english, 2020

36

Targeting interleukin-4 to the arthritic joint

Spieler, Valerie, Ludwig, Marie-Gabrielle, Dawson, Janet, Tigani, Bruno, Littlewood-Evans, Amanda, Safina, Caterina, Ebersbach, Hilmar, Seuwen, Klaus, Raschig, Martina, ter Mors, BjÃ¶rn, MÃ¼ller, Thom

Journal:

Journal of Controlled Release

Year:

2020

File:

PDF, 1.39 MB

2020

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